i hope this doesn't offend anyone but the only "medication" that has never let me down to this date has been psilocybin... one heroic dose in a berry smoothie gives me a sense of well being beyond measure and completely lifts my depression... the effects can last for upto four weeks before i have to re-dose again... i take enough to guarantee ego loss every time... it's quite spiritual... isn't it amazing that nature has evolved along with us, she is capable of providing for all our needs if we just open our minds to it... pharmaceutical companies know this, they study plant molecules and try to come up with something similar in their labs so that they can patent it and sell it to us... thing is, these man made molecules are never as effective and typically causes side effects... why not just allow us to consume the organism as it is found in nature?
Kensho
